Doxycycline Hyclate

Doxycycline Hyclate

API’s Name:Doxycycline Hyclate

CAS No.:24390-14-5

Indication:Antibiotics

Innovator

Specification:USP/EP

US DMF:13771

EU DMF:√

CEP

Only for R&D purpose

Intermediates


Product Detail

Background

Doxycycline hyclate is an antibiotic [1].


Doxycycline hyclate is a derivative of tetracycline and possesses the activities of anti-inflammatory and antimicrobial. Doxycycline inhibits dengue virus replication in vitro with a temperature-dependent manner. The IC50 value is 52.3μM at 37°C and 26.7μM at 40°C. It inhibits the dengue virus via inhibiting the NS2B-NS3 serine protease of the virus. 60μM doxycycline reduces the CPE of the DNEV2-infected cells [1].


Doxycycline is found to be an inhibitor of MMP. Doxycycline treatment reduces MMP-8 and -9 levels and inhibits expression of tissue MMP-2 and MMP-9. Moreover, treatment with doxycycline significantly reduces the incidence of intracranial aneurysms. Doxycycline has also been reported to be an anti-inflammatory agent based on its inhibition of matrix metalloproteinases. In addition, doxycycline has potent antimalarial activity with IC50 value of 320nM at 96h in vitro [2, 3].


References:

[1] Rothan HA, Mohamed Z, Paydar M, Rahman NA, Yusof R. Inhibitory effect of doxycycline against dengue virus replication in vitro. Arch Virol. 2014 Apr;159(4):711-8.

[2] Maradni A, Khoshnevisan A, Mousavi SH, Emamirazavi SH, Noruzijavidan A. Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article. Med J Islam Repub Iran. 2013 Nov;27(4):249-254.

[3] Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML. In vitro and in vivo antimalarial efficacies of optimized tetracyclines. Antimicrob Agents Chemother. 2013 Jul;57(7):3131-6.


Description

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1].


Clinical Trial

NCT Number

Sponsor

Condition

Start Date

Phase

NCT00246324

Louisiana State University Health Sciences Center Shreveport|Biogen

Multiple Sclerosis

December 2003

Phase 4

NCT00910715

University Medical Centre Ljubljana

Erythema Chronicum Migrans

June 2009

Not Applicable

NCT00243893

University of California, San Francisco|National Institute of Neurological Disorders and Stroke (NINDS)

Aneurysms|Arteriovenous Malformations

July 2004

Phase 1

NCT00126399

CollaGenex Pharmaceuticals

Rosacea

June 2004

Phase 3

NCT01318356

Radboud University|ZonMw: The Netherlands Organisation for Health Research and Development

Q Fever|Fatigue Syndrome, Chronic|Coxiella Infection

April 2011

Phase 4

NCT00177333

University of Pittsburgh

Abortion, Induced|Vomiting

September 2005

Phase 4

NCT00007735

US Department of Veterans Affairs|Pfizer|United States Department of Defense|VA Office of Research and Development

Persian Gulf Syndrome|Mycoplasma Infections

January 1999

Phase 3

NCT00351273

University of South Florida|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Arthritis, Reactive|Reiter Disease

May 2006

Phase 3

NCT00469261

Careggi Hospital

Myocardial Infarction|Left Ventricular Remodeling

May 2007

Phase 2

NCT00547170

University of Pittsburgh|Tu Du Hospital

Endometritis

January 2007

Phase 4

NCT01475708

University Medical Centre Ljubljana

Lyme Borreliosis

May 2011


NCT01368341

Morten Lindbaek|Norwegian Institute of Public Health|Sorlandet Hospital HF|Norwegian University of Life Sciences|University of Oslo

Erythema Migrans|Erythema Chronicum Migrans|Borreliosis|Lyme Disease|Early Lyme Disease

June 2011

Phase 4

NCT02538224

Islamic Azad University, Tehran

Chronic Periodontitis

July 2013

Phase 2|Phase 3

NCT00066027

University of Nebraska|National Institute of Dental and Craniofacial Research (NIDCR)

Periodontitis

June 2002

Phase 3

NCT00376493

Hospital de Clinicas de Porto Alegre

Septic Abortion

May 2006

Phase 4

NCT03448731

Fundacion CRIS de Investigación para Vencer el Cáncer|Amgen|Apices Soluciones S.L.

Skin Toxicity

May 10, 2018

Phase 2

NCT00989742

University of Nottingham

Lymphangioleiomyomatosis|Tuberous Sclerosis

July 2009

Phase 4

NCT01438515

Horizon Health Network

Methicillin-resistant Staphylococcus Aureus

August 2008

Not Applicable

NCT02929121

The Task Force for Global Health|United States Agency for International Development (USAID)

Lymphedema|Lymphatic Filariasis|Filariasis

January 15, 2019

Phase 3

NCT00952861

Odense University Hospital|Kolding Sygehus|Svendborg Hospital|Fredericia Hospital|Naestved Hospital|Hillerod Hospital, Denmark|Region Syddanmark|Danmarks Lungeforening|Danish National Research Foundation

Pulmonary Disease, Chronic Obstructive

October 2009

Phase 4

NCT00138801

Sorlandet Hospital HF

Lyme Neuroborreliosis

March 2004

Phase 3

NCT00942006

University Medical Centre Ljubljana

Suspected Early Lyme Neuroborreliosis

July 2009

Not Applicable

NCT02713607

University of California, Davis

Acne Vulgaris

March 2016

Phase 1|Phase 2

NCT00560703

Galderma

Blepharitis|Meibomianitis|Dry Eye

November 2007

Phase 2

NCT01014260

Johns Hopkins University

Cardiovascular Disease

September 2010

Phase 4

NCT00000938

National Institute of Allergy and Infectious Diseases (NIAID)

Lyme Disease


Phase 3

NCT01398072

University College, London|Royal Free Hampstead NHS Trust|University of Cambridge|National Institute for Health Research, United Kingdom

Chronic Obstructive Pulmonary Disease (COPD).

December 2011

Phase 3

NCT03479502

Vanderbilt University Medical Center|Orthopedic Research and Education Foundation

Adhesive Capsulitis|Adhesive Capsulitis of Unspecified Shoulder|Frozen Shoulder

January 5, 2018

Phase 4

NCT02929134

The Task Force for Global Health|United States Agency for International Development (USAID)

Lymphedema|Lymphatic Filariasis|Filariasis

February 16, 2018

Phase 3

NCT00480532

Oregon Health and Science University

Contraceptives, Oral

May 2007

Not Applicable

NCT01594827

Johns Hopkins University|Case Western Reserve University|Cystic Fibrosis Foundation

Cystic Fibrosis

October 2012

Phase 2

NCT01744093

Weill Medical College of Cornell University|National Heart, Lung, and Blood Institute (NHLBI)

HIV|Chronic Obstructive Pulmonary Disease (COPD)|Emphysema

July 17, 2014

Not Applicable

NCT03530319

National Taiwan University Hospital

Pneumonia, Mycoplasma

November 10, 2018

Not Applicable

NCT04167085

University of California, Los Angeles

Epistaxis

December 18, 2017

Phase 4

NCT01411202

Ottawa Hospital Research Institute

Malignant Pleural Effusion

June 2011

Phase 2

NCT01474590

Galderma

Acne

November 2011

Phase 3

NCT00649571

Mylan Pharmaceuticals

Healthy

July 2005

Phase 1

NCT02899000

Galderma Laboratories, L.P.

Acne Vulgaris

July 29, 2016

Phase 4

NCT00538967

Leiden University Medical Center

Aortic Aneurysm, Abdominal

May 2002

Phase 2

NCT00439400

Alacrity Biosciences, Inc.

Dry Eye

February 2007

Phase 2

NCT00917553

Thomas Gardner|Penn State University|Juvenile Diabetes Research Foundation|Milton S. Hershey Medical Center

Diabetic Retinopathy

July 2009

Phase 2

NCT00495313

CollaGenex Pharmaceuticals

Rosacea

March 2007

Phase 4

NCT01855360

Brigham and Women´s Hospital

Amyloidosis; Heart (Manifestation)|Senile Cardiac Amyloidosis

June 2013

Phase 1|Phase 2

NCT00419848

Shahid Beheshti University of Medical Sciences

Acne

August 2006

Phase 2

NCT03532464

University Hospital, Bordeaux|USC EA 3671 Infections humaines à mycoplasmes et à chlamydiae

Chlamydia Trachomatis Infection|Vaginal Infection|Anal Infection

July 1, 2018

Phase 4

NCT02756403

Medstar Health Research Institute|Society of Family Planning

First Trimester Abortion

March 2016

Not Applicable

NCT00353158

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institutes of Health Clinical Center (CC)

Healthy Volunteers|Fungal Infections|Bacterial Infections

July 11, 2006

Phase 1

NCT01317433

Institut Cancerologie de l´Ouest

Colorectal Cancer Metastatic|Skin Toxicity

December 2010

Phase 3

NCT01658995

Petra M. Casey|Mayo Clinic

ESI-related Bleeding

September 13, 2012

Phase 3

NCT03968562

State University of New York - Downstate Medical Center

Hives

May 15, 2019

Phase 2

NCT02569437

Icahn School of Medicine at Mount Sinai

Polyp of Nasal Sinus

September 2014

Phase 2

NCT01198509

NYU Langone Health|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|Memorial Sloan Kettering Cancer Center

Rheumatoid Arthritis|Psoriatic Arthritis|Periodontal Disease

January 2010

Not Applicable

NCT01163994

University Medical Centre Ljubljana

Multiple Erythema Migrans

June 2010

Not Applicable

NCT02388477

Milton S. Hershey Medical Center

Rotator Cuff Injury


Not Applicable

NCT01010295

International Extranodal Lymphoma Study Group (IELSG)

Non-Hodgkin Lymphoma

September 2006

Phase 2

NCT00775918

Ranbaxy Laboratories Limited|Ranbaxy Inc.

Healthy

June 2005

Not Applicable

NCT04050540

University of Washington|Kenya Medical Research Institute|Kenya National AIDS & STI Control Programme|University of California, San Francisco|National Institute of Allergy and Infectious Diseases (NIAID)

HIV Infections|HIV+AIDS|Neisseria Gonorrheae Infection|Chlamydia Trachomatis Infection|Syphilis Infection

February 5, 2020

Phase 4

NCT02562651

Russian Academy of Medical Sciences

Vascular Diseases|Cardiovascular Diseases|Acute Myocardial Infarction

February 2014

Phase 2|Phase 3

NCT00001101

National Institute of Allergy and Infectious Diseases (NIAID)

Lyme Disease


Phase 3

NCT00340691

National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC)

Mansonella Perstans Infection|Mp Microfilaremia

December 6, 2004

Phase 2

NCT01112059

University of Alabama at Birmingham|Cystic Fibrosis Foundation

Cystic Fibrosis

November 2008

Not Applicable

NCT00652704

Par Pharmaceutical, Inc.|Anapharm

To Determine Bioequivalence Under Fed Conditions

July 1999

Phase 1

NCT01783860

Tehran University of Medical Sciences

Posterior Blepharitis

January 2013

Phase 2

NCT02564471

State University of New York - Upstate Medical University|Walter Reed Army Institute of Research (WRAIR)|Kansas State University

Rabies

April 2016

Phase 4

NCT04206631

Indonesia University

Acne Vulgaris

April 1, 2015

Phase 1

NCT03956446

University Medical Centre Ljubljana|University of Ljubljana School of Medicine, Slovenia

Tick Borne Encephalitis

September 1, 2014

Not Applicable

NCT03960411

Felix Chikita Fredy, MD|National Cardiovascular Center Harapan Kita Hospital Indonesia|Indonesia University

ST Elevation Myocardial Infarction|Anterior Wall Myocardial Infarction|Heart Failure|Remodeling, Ventricular

May 25, 2019

Phase 3

NCT00322465

National Institute of Allergy and Infectious Diseases (NIAID)

Urethritis

November 2006

Phase 2

NCT01375491

University of California, San Diego|Ruth L. Kirschstein National Research Service Award|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Center for Research Resources (NCRR)

Type 2 Diabetes|Obesity

October 2009

Phase 4

NCT03478436

Medical University of Vienna|Dr. Reddy´s Laboratories Limited

Rosacea

July 2016

Phase 1

NCT01207739

Radboud University|Sint Maartenskliniek|ZonMw: The Netherlands Organisation for Health Research and Development

Lyme Disease|Borrelia Infection

September 2010

Phase 4

NCT00939562

Pfizer

Bacterial Infection

November 2008

Phase 4

NCT03608774

National Institute of Allergy and Infectious Diseases (NIAID)

Anal Chlamydia Infection

June 26, 2018

Phase 4

NCT02281643

Kwame Nkrumah University of Science and Technology|University of Bonn|Heinrich-Heine University, Duesseldorf

Mansonella Perstans Infection|Buruli Ulcer|Tuberculosis|Co-infection

October 2014

Phase 2

NCT00066066

The Forsyth Institute|National Institute of Dental and Craniofacial Research (NIDCR)

Periodontitis|Periodontal Diseases

July 2003

Phase 2

NCT01798225

Medical University of South Carolina|National Center for Research Resources (NCRR)

Periodontal Disease|Type 2 Diabetes Mellitus

December 2007

Phase 4

NCT00612573

Warner Chilcott

Acne Vulgaris

February 2008

Phase 2

NCT01631617

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institutes of Health Clinical Center (CC)

Eczema|Dermatitis|Skin Diseases, Genetic|Dermatitis, Atopic|Skin Diseases

September 18, 2012

Phase 2

NCT03173053

Radboud University|ZonMw: The Netherlands Organisation for Health Research and Development|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Aalborg University Hospital|Rigshospitalet, Denmark

Staphylococcus Aureus|Motility Disorder

February 8, 2018

Not Applicable

NCT00715858

McMaster University|The Physicians´ Services Incorporated Foundation

Alzheimer´s Disease

May 2008

Phase 3

NCT03584919

University Medical Centre Ljubljana

Erythema Chronicum Migrans

June 1, 2006

Not Applicable

NCT01469585

University of Hawaii|Charles Drew University of Medicine and Science|Meharry Medical College

Breakthrough Bleeding

November 2011

Not Applicable

NCT02759120

Weill Medical College of Cornell University|Duke Clinical Research Institute|University of Chicago|University of Washington|University of Pittsburgh|National Heart, Lung, and Blood Institute (NHLBI)

Idiopathic Pulmonary Fibrosis

March 22, 2017

Phase 3

NCT02735837

Amirhossein Farahmand|Islamic Azad University, Tehran

Diabetes Mellitus With Periodontal Disease

January 2015

Phase 2|Phase 3

NCT03655197

University of California, Davis

Rosacea|Ocular Rosacea|Cutaneous Rosacea

November 2, 2017

Early Phase 1

NCT01188954

Northwell Health

Seroma

January 2010

Not Applicable

NCT00388778

Shahid Beheshti University of Medical Sciences

Acne|Inflammation

October 2005

Phase 2|Phase 3

NCT01087476

Metropolitan Autonomous University|Instituto Nacional de Cancerologia de Mexico

Mucositis

May 2010

Phase 2

NCT02174757

CD Pharma India Pvt. Ltd.|Sree Mookambika Institute of Dental Sciences

Chronic Periodontitis

August 2014

Phase 3

NCT03911440

National Taiwan University Hospital

Atypical Pneumonia

November 10, 2018

Not Applicable

NCT02553083

Rabin Medical Center

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

October 22, 2015

Phase 4

NCT04234945

Ahmadu Bello University Teaching Hospital

Infertility, Female|Pelvic Inflammatory Disease

January 13, 2020

Not Applicable

NCT00892281

Galderma Laboratories, L.P.

Rosacea

April 2009

Phase 4

NCT02913118

Qingfeng Pharmaceutical Group

Community Acquired Pneumonia

July 2016

Phase 4

NCT04153604

Methodist Health System

Cirrhosis|Spontaneous Bacterial Peritonitis

November 4, 2019


NCT03153267

University Medical Centre Ljubljana|University of Ljubljana School of Medicine, Slovenia

Erythema Chronicum Migrans

June 1, 2017

Not Applicable

NCT03116659

James J. Peters Veterans Affairs Medical Center

Lymphoma, T-Cell, Cutaneous

February 1, 2018

Early Phase 1

NCT03401372

Jian Li|Peking University First Hospital|Chinese PLA General Hospital|Beijing Chao Yang Hospital|West China Hospital Affiliated with Sichuan University|Tongji Hospital Affiliated with Tongji Medical College of HUST|Union Hospital Affiliated with Tongji Medical College of HUST|Shanghai Changzheng Hospital|Nanfang Hospital of Southern Medical University|Peking Union Medical College Hospital

Amyloidosis; Systemic

April 21, 2018

Not Applicable

NCT01380496

Par Pharmaceutical, Inc.|Anapharm

To Determine Bioequivalence Under Fed Conditions

November 1999

Phase 1

NCT03083197

University of Oxford|Shoklo Malaria Research Unit|Chiangrai Prachanukroh Hospital

Scrub Typhus

October 15, 2017

Phase 4

NCT00237016

Medical Corps, Israel Defense Force

Relapsing Fever, Tick-Borne|Jarisch Herxheimer Reaction

April 2002

Phase 2|Phase 3

NCT01308619

Galderma Laboratories, L.P.

Rosacea

April 2011

Phase 4

NCT01198912

University Hospital, Ghent

Chronic Rhinosinusitis|Nasal Polyps

November 22, 2011

Phase 2

NCT02016365

Umeå University

Transthyretin Amyloidosis|Cardiomyopathy

February 2012

Phase 2

NCT00783523

University of California, San Francisco

Arteriovenous Malformations|Cavernous Angiomas|Brain Aneurysms

March 2008

Phase 1

NCT03337932

University Medical Centre Ljubljana

Erythema Chronicum Migrans

January 1, 2018

Not Applicable

NCT00568711

Dong-Min Kim|Chosun University Hospital

Scrub Typhus

September 2006

Not Applicable

NCT01874860

University of Louisville|James Graham Brown Cancer Center

Colorectal Cancer|Head and Neck Cancer

August 2013

Phase 2

NCT01171859

IRCCS Policlinico S. Matteo

Transthyretin Amyloidosis

July 2010

Phase 2

NCT01653522

The Cleveland Clinic

Migraine Disorders|Headache, Migraine|Migraine|Migraine Headache|Migraine With Aura|Migraine Without Aura|Headache Disorders, Primary

July 2012

Not Applicable

NCT01820910

International Extranodal Lymphoma Study Group (IELSG)

Marginal Zone Lymphoma of Ocular Adnexal

March 2013

Phase 2

NCT01323101

University of Southern California

Cystic Fibrosis

April 2008

Phase 4

NCT00829764

Teva Pharmaceuticals USA

Healthy

October 2006

Phase 1

NCT01668498

AIO-Studien-gGmbH

Ras-wildtype Colorectal Cancer

May 2011

Phase 2

NCT01030666

Peter Eickholz|Heidelberg University|Dr. August Wolff GmbH & Co. KG Arzneimittel|Gaba International AG|Goethe University

Periodontitis

April 2007

Phase 4

NCT00012688

US Department of Veterans Affairs|Colgate-Periogard-Dentsply|VA Office of Research and Development

Diabetes Mellitus|Poor Glycemic Control|Peridontal Disease


Not Applicable

NCT01885910

Derm Research, PLLC|WFH MEDICAL, LLC

Acne Vulgaris

July 2013

Phase 4

NCT02328469

University Medical Centre Ljubljana|Slovenian Research Agency|University of Ljubljana School of Medicine, Slovenia|Harvard University

Aseptic Meningitis

June 2014


NCT00355602

University of Dundee|Tenovus Scotland

Colitis, Ulcerative

July 2006

Not Applicable

NCT02606032

Hamilton Health Sciences Corporation|Hamilton Academic Health Sciences Organization

Ulcerative Colitis

May 2016

Phase 2

NCT01465802

Pfizer

Non Small Cell Lung Cancer (NSCLC)

December 26, 2011

Phase 2

NCT02623959

M.D. Anderson Cancer Center

Advanced Cancers|Malignant Pleural Effusions

April 27, 2016

Phase 4

NCT03481972

IRCCS Policlinico S. Matteo

TTR Cardiac Amyloidosis

April 11, 2018

Phase 3

NCT00428818

University of Texas Southwestern Medical Center

Infection

August 2005

Not Applicable

NCT01935622

Virginia Commonwealth University

Non-ischemic Cardiomyopathy|Systolic Heart Failure (NYHA II-III)

July 2012

Phase 2

NCT01886560

Sun Yat-sen University

Eye Burns

September 2013

Phase 2|Phase 3

NCT04239755

Damanhour University|Tanta University

Traumatic Brain Injury

December 15, 2019

Phase 4

NCT02204254

Centre Hospitalier Universitaire de Nice

Rosacea

March 2014

Not Applicable

NCT00837213

Stiefel, a GSK Company|GlaxoSmithKline

Acne

August 2007

Phase 4

NCT03115177

Rush University Medical Center

Osteoarthritis

November 2015

Not Applicable

NCT03618108

Cadrock Pty. Ltd.|Centre for Digestive Diseases, Australia

Coronary Heart Disease|Chlamydophila Pneumoniae Infections

April 4, 2018

Phase 2

NCT03435952

M.D. Anderson Cancer Center|BioMed Valley Discoveries, Inc|Merck Sharp & Dohme Corp.

Malignant Neoplasm of Breast|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites|Malignant Neoplasms of Independent (Primary) Multiple Sites|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract

July 10, 2018

Phase 1

NCT01867294

Academic and Community Cancer Research United|National Cancer Institute (NCI)

Advanced Malignant Neoplasm|Dermatologic Complication

August 31, 2012

Phase 2

NCT01677286

Boston University

Amyloidosis

July 2012

Phase 2

NCT00511875

Thomas Gardner|Juvenile Diabetes Research Foundation|Milton S. Hershey Medical Center

Diabetic Retinopathy

July 2008

Phase 2

NCT04108897

Johns Hopkins University

Rosacea

September 17, 2019

Early Phase 1

NCT00631501

Kaunas University of Medicine|University Hospital, Linkoeping

Lateral Epicondylalgia (Tennis Elbow)


Not Applicable

NCT02203682

Sun Yat-sen University

Graves Ophthalmopathy|Graves Disease|Eye Diseases|Thyroid Diseases|Endocrine System Diseases|Eye Diseases, Hereditary|Hyperthyroidism|Autoimmune Diseases|Immune System Diseases

July 2014

Phase 2

NCT02005653

Indian Council of Medical Research

Filarial; Infestation

February 2009

Phase 4

NCT03585140

Centro Dermatológico Dr. Ladislao de la Pascua

Acne Vulgaris|Diet Modification

January 1, 2016

Not Applicable

NCT02147262

University Medical Centre Ljubljana|University of Ljubljana School of Medicine, Slovenia|Medical University of Vienna|Harvard University

Chronic Atrophic Acrodermatitis

July 2013

Not Applicable

NCT02220751

University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo

Periodontitis|Type 2 Diabetes Mellitus

March 2009

Phase 3

NCT01825408

University of North Carolina, Chapel Hill

Sinusitis

February 2013

Phase 4

NCT02884713

King Faisal Specialist Hospital & Research Center

GASTRITIS

June 2013

Not Applicable

NCT02726646

University of Campinas, Brazil|Pontificia Universidade Catolica de Sao Paulo

Chronic Periodontitis

June 2015

Phase 2

NCT00883818

Samsung Medical Center

Overactive Bladder

January 2007

Phase 4

NCT00829790

Teva Pharmaceuticals USA

Healthy

October 2006

Phase 1

NCT01949233

University of Oxford|Oxford University Hospitals NHS Trust

Marfan Syndrome

October 2013

Phase 2

NCT01518192

University Medical Centre Ljubljana|Slovenian Research Agency

Erythema Migrans|Post-Lyme Disease Symptoms

June 2006

Phase 4

NCT02845024

Islamic Azad University, Tehran

Diabetes Mellitus With Periodontal Disease

September 2014

Not Applicable

NCT01879930

University Hospital Inselspital, Berne

Chronic Pelvic Pain Syndrome|Bladder Pain Syndrome

November 2012

Phase 4

NCT00041977

CollaGenex Pharmaceuticals

Acne Rosacea

June 2002

Phase 3

NCT02341209

Rochester General Hospital

Cutaneous T-cell Lymphoma|Mycosis Fungoides|Sezary Syndrome

February 6, 2018

Phase 2

NCT00002872

Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|North Central Cancer Treatment Group

Metastatic Cancer

November 1996

Phase 3

NCT03162497

Medical University of Vienna

Dry Eye Syndromes|Meibomian Gland Dysfunction

January 8, 2018

Phase 4

NCT01418742

Gesellschaft fur Medizinische Innovation ? Hamatologie und Onkologie mbH|ClinAssess GmbH

Colorectal Carcinoma

August 2011

Phase 2

NCT00980148

National Institute of Allergy and Infectious Diseases (NIAID)

Chlamydial Infection

December 2009

Phase 3

NCT03342456

The Third Xiangya Hospital of Central South University|Livzon Pharmaceutical Group Inc.|Yung Shin Pharm. Ind. Co., Ltd.

Duodenal Ulcer Due to Helicobacter Pylori

December 13, 2017

Phase 4

NCT04310930

The University of Queensland|Australian Government Department of Health|Children´s Hospital Foundation|Cystic Fibrosis Foundation|Newcastle University|Griffith University|Erasmus Medical Center|Monash University|University of Copenhagen|Hôpital Cochin|South Australian Health and Medical Research Institute|University of Melbourne|James Cook University, Queensland, Australia|Murdoch Childrens Research Institute

Pulmonary Disease Due to Mycobacteria (Diagnosis)

March 2020

Phase 2|Phase 3

NCT03709459

Kirby Institute|South Australian Health and Medical Research Institute|Monash University

STIs Prevention

December 17, 2019


NCT04067011

Emergent BioSolutions|Biomedical Advanced Research and Development Authority

Anthrax

August 12, 2019

Phase 2

NCT02844634

British Columbia Centre for Disease Control

HIV|Syphilis

May 15, 2018

Phase 4

NCT00647959

Mylan Pharmaceuticals

Healthy

March 2006

Phase 1

NCT00170222

Medical Center Alkmaar

Chronic Obstructive Pulmonary Disease

July 2002

Phase 4

NCT03075891

Galderma

Rosacea

July 5, 2017

Phase 4

NCT00031499

National Institute of Allergy and Infectious Diseases (NIAID)

Syphilis

June 2000

Phase 3

NCT01205464

Linkoeping University

Fatigue|Radicular Pain|Cognitive Dysfunction|Paresthesia|Paresis

February 2005

Not Applicable

NCT01301586

Nexgen Dermatologics, Inc.

ACNE VULGARIS

November 2010

Phase 1|Phase 2

NCT02305940

Imperial College London

Chronic Obstructive Pulmonary Disease (COPD)

July 2014

Phase 3

NCT00351182

Dong-Min Kim|Chosun University Hospital

Scrub Typhus

September 2005

Phase 3

NCT03334682

Nantes University Hospital

Acne Vulgaris

January 31, 2018

Phase 3

NCT01788215

University of Rochester

Polycystic Ovarian Syndrome (PCOS)|Irregular Menstrual Cycles|Androgen Excess

November 2010

Phase 3

NCT03076281

Sidney Kimmel Cancer Center at Thomas Jefferson University|Thomas Jefferson University

Larynx|LIP|Oral Cavity|Pharynx

April 3, 2017

Phase 2

NCT00439166

Hamilton Health Sciences Corporation|The Physicians´ Services Incorporated Foundation|McMaster University

Alzheimer´s Disease

February 2007

Phase 3

NCT02463942

University Medical Centre Ljubljana|University of Ljubljana School of Medicine, Slovenia

Tick-borne Encephalitis

September 2014

Not Applicable

NCT00803842

Northwestern University

Non Small Cell Lung Cancer

October 2008

Not Applicable

NCT02086591

University of Rochester

Adult Diffuse Large B-Cell Lymphoma|Mantle Cell Lymphoma Recurrent|Lymphoma, Follicular|Marginal Zone B-Cell Lymphoma|Malignant Lymphoma - Lymphoplasmacytic|Waldenstrom Macroglobulinemia|Small Lymphocytic Lymphoma|Chronic Lymphocytic Leukemia (CLL)|T-Cell Lymphoma

March 2014

Phase 2

NCT03980223

University of California, San Francisco|University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)|Mayne Pharma International Pty Ltd|San Francisco Department of Public Health

Gonorrhea|Chlamydia|Syphilis

November 26, 2019

Phase 4

NCT00355459

University of Texas Southwestern Medical Center

Dry Eye Syndrome

August 2005

Not Applicable

NCT01254799

Omar Mamdouh Shaaban|Assiut University

Uterine Hemorrhage

January 2008

Phase 3

NCT01547325

NanoSHIFT LLC|United States Department of Defense

Dehisced Surgical Wounds

May 2012

Not Applicable

NCT00653380

Par Pharmaceutical, Inc.|Anapharm

To Determine Bioequivalence Under Fasting Conditions

September 1999

Phase 1

NCT00635609

Warner Chilcott

Acne Vulgaris

March 2008

Phase 4

NCT03765931

Institut de Recherche pour le Developpement

Fever

July 2016

Phase 4

NCT01160640

Harold Wiesenfeld|National Institute of Allergy and Infectious Diseases (NIAID)|University of Pittsburgh

Pelvic Inflammatory Disease

November 2010

Phase 2

NCT01756833

University of Maryland, Baltimore|National Institute on Aging (NIA)

Aneurysm

May 2013

Phase 2

NCT00688064

Galderma

Severe Acne Vulgaris

August 2008

Phase 3

NCT01320033

Galderma

Acne Vulgaris

March 29, 2011

Phase 2

NCT03397004

St. Michael´s Hospital, Toronto|Barrow Neurological Institute|Duke University|Feinstein Institute for Medical Research|University of Pittsburgh|Sunnybrook Health Sciences Centre

Hereditary Hemorrhagic Telangiectasia (HHT)

September 12, 2018

Phase 2

NCT01635530

Turku University Hospital

Lyme Neuroborreliosis

August 2012

Phase 4

NCT03727620

Mohammed V Souissi University

Aggressive Periodontitis

January 6, 2014

Phase 1|Phase 2

NCT02688738

Rothman Institute Orthopaedics

Propionibacterium

March 2015

Not Applicable

NCT00358462

University of Washington|National Institute of Allergy and Infectious Diseases (NIAID)

Urethritis

January 2007

Phase 3

NCT02864550

British Columbia Centre for Disease Control

Syphilis|Sexually Transmitted Infections

August 15, 2019

Phase 4

NCT01595594

University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo

Periodontal Disease|Type 2 Diabetes

March 2010

Phase 3

NCT00964834

PharmAthene, Inc.|National Institutes of Health (NIH)|Medarex|Quintiles, Inc.|Department of Health and Human Services

Anthrax

July 2009

Phase 1

NCT01809444

Sun Yat-sen University

Thyroid Associated Opthalmopathies

November 2012

Phase 2|Phase 3

NCT01590082

M.D. Anderson Cancer Center|National Institutes of Health (NIH)|National Cancer Institute (NCI)

Melanoma

November 2012

Phase 1|Phase 2

NCT00207584

Centers for Disease Control and Prevention

Mycoplasma Pneumoniae

January 1994

Not Applicable

NCT00775177

Ranbaxy Laboratories Limited|Ranbaxy Inc.

Healthy

June 2005

Not Applicable

NCT03462329

University Medical Centre Ljubljana

Erythema Migrans

June 1, 2018

Not Applicable

NCT00000403

Indiana University|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|National Institute on Aging (NIA)

Osteoarthritis

September 1996

Phase 3

NCT03508232

University of Alberta|Royal Alexandra Hospital

ST Segment Elevation Myocardial Infarction|Heart Failure

January 6, 2020

Phase 2

NCT02553473

Sorlandet Hospital HF

Neuroborreliosis, Borrelia Burgdorferi

October 2015

Phase 3

NCT02207556

Medical College of Wisconsin

Primary Systemic Amyloidosis

October 1, 2014

Phase 2

NCT01783106

Royal Liverpool University Hospital|National Association for Colitis and Crohn´s Disease|National Institute for Health Research, United Kingdom

Crohn´s Disease

February 1, 2014

Phase 2

NCT00353743

Hospital de Clinicas de Porto Alegre

Abortion, Septic

May 2006

Not Applicable

NCT01727973

Sun Yat-sen University

Graves Ophthalmopathy|Graves Disease|Eye Diseases|Thyroid Diseases|Endocrine System Diseases|Eye Diseases, Hereditary|Hyperthyroidism|Autoimmune Diseases|Immune System Diseases

October 2012

Phase 1|Phase 2

NCT00857038

Medical Center Alkmaar|Leiden University Medical Center|University of Amsterdam

Chronic Obstructive Pulmonary Disease|Inflammation|Pulmonary Emphysema

April 2009

Phase 4

NCT02774993

National University Hospital, Singapore|Tan Tock Seng Hospital|National University, Singapore|A*Star

Tuberculosis

September 2015

Phase 2

NCT03474458

IRCCS Policlinico S. Matteo

Cardiac AL Amyloidosis

February 11, 2019

Phase 2|Phase 3

NCT02874430

Sidney Kimmel Cancer Center at Thomas Jefferson University|Thomas Jefferson University

Breast Carcinoma|Endometrial Clear Cell Adenocarcinoma|Endometrial Serous Adenocarcinoma|Uterine Corpus Cancer|Uterine Corpus Carcinosarcoma

June 8, 2016

Phase 2

NCT00016835

University of Michigan|National Institute of Dental and Craniofacial Research (NIDCR)

Periodontal Disease|Diabetes Mellitus, Type 2

October 17, 2001

Phase 2

NCT00064766

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Endometrial Bleeding|Periodontal Disease

February 2003

Phase 4

NCT00803452

University of Louisville

Blepharitis

July 2008

Phase 4

NCT01434173

Bayer|RTI Health Solutions

Drug-Induced Liver Injury

July 2001


NCT00126204

Barnes-Jewish Hospital

Aortic Aneurysm

March 2004

Not Applicable

NCT01917721

Hawaii Pacific Health

Kawasaki Disease|Coronary Aneurysm

October 2013

Phase 2

NCT02775695

Medical College of Wisconsin

Resectable Pancreatic Cancer

April 3, 2017

Phase 2

NCT03824340

Aljazeera Hospital

Infertility

January 30, 2019

Not Applicable

NCT01847976

Ottawa Hospital Research Institute|Canadian Breast Cancer Foundation

Pain

August 2013

Phase 2

NCT02850913

Makerere University|University of Oxford

Seizures

September 5, 2016

Phase 2

NCT00764361

NanoSHIFT LLC

Diabetic Foot Ulcer

January 2009

Phase 2

NCT02036528

Royer Biomedical, Inc.

Diabetic Foot Ulcers

January 2014

Phase 1|Phase 2

NCT01661985

Ostergotland County Council, Sweden|Statens Serum Institut

Urethritis|Cervicitis|Genital Mycoplasma Infection|Chlamydia Trachomatis

February 2010

Phase 4

NCT01380483

Par Pharmaceutical, Inc.|Anapharm

To Determine Bioequivalence Under Fasting Conditions

January 2000

Phase 1

NCT00648180

Mylan Pharmaceuticals

Healthy

July 2005

Phase 1

NCT01426269

Galderma Laboratories, L.P.

Rosacea

September 2011

Phase 4

NCT02753426

University of California, San Francisco

Chronic Kidney Disease|Cardiorenal Syndrome

April 2016

Phase 1

NCT02583282

Postgraduate Institute of Medical Education and Research

Malignant Pleural Effusion

August 1, 2015

Not Applicable

NCT02927496

The Task Force for Global Health|United States Agency for International Development (USAID)

Lymphedema|Lymphatic Filariasis|Filariasis

June 19, 2018

Phase 3

NCT00652795

Par Pharmaceutical, Inc.|Anapharm

To Determine Bioequivalence Under Fasting Conditions

July 2004

Phase 1

NCT03956212

University Medical Centre Ljubljana|University of Ljubljana School of Medicine, Slovenia

Erythema Migrans

June 1, 2017

Not Applicable

NCT00855595

Bayer

Papulopustular Rosacea

February 2009

Phase 4

NCT03457636

Derm Research, PLLC

Acne

March 19, 2018

Phase 4

NCT02894268

Sir Run Run Shaw Hospital

Helicobacter Pylori Infection

February 2016

Phase 4

NCT03465774

M.D. Anderson Cancer Center|National Cancer Institute (NCI)

Malignant Pleural Effusion

March 8, 2018

Early Phase 1

Chemical structur

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